By Sylvain Choquet

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The trial was a non-inferiority, randomized study powered to exclude a ≥7 % difference in PFS of the experimental arm vs. the standard arm, and therefore the endpoint was met. 8 % for the NFT arm. Moreover, as further confounding factor, all the 5 deaths recorded in the study occurred in patients allocated to IFRT arm, before starting radiation therapy. 39 PET Response-Adapted Treatment in Hodgkin Lymphoma Intention-to-Treat Analysis a 100 Radiotherapy 90 Progression-free Survival (%) Fig. 5 Final results of the UK NCRI RAPID trial: progression-free survival of irradiated vs.

For these reasons at the beginning of the 1980s, radiological imaging with lymphography and CeCT surmounted staging laparotomy. CeCT, in particular, proved a readily accessible, non-invasive diagnostic tool, with a high sensitivity and overall accuracy for tumour spread detection and it became rapidly the standard for tumour staging [21]. In the meanwhile, the growing evidence that the tumour per se and the host reaction against the tumour were the main prognostic parameters correlated to tumour survival provided the frame for a new classification of prognostic factors in HL as (1) tumour-related, (2) host-related, and (3) environment-related [22].

Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, Lister TA, Vose J, Grillo-López A, Hagenbeek A, Cabanillas F, Klippensten D, Hiddemann W, Castellino R, Harris NL, Armitage JO, Carter W, Hoppe R, Canellos GP. Report of an international workshop to standardize response criteria for nonHodgkin’s lymphomas. NCI Sponsored International Working Group. J Clin Oncol. 1999;17:1244. 5. Hoekstra OS, Ossenkoppele GJ, Golding R, van Lingen A, Visser GW, Teule GJ, Huijgens PC. Early treatment response in malignant lymphoma, as determined by planar fluorine-18-fluorodeoxyglucose scintigraphy.

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