By Mehmet Sengun Ozsoz

This ebook specializes in the fundamental electrochemical functions of DNA in quite a few parts, from easy ideas to the newest discoveries. The publication contains theoretical and experimental research of varied houses of nucleic acids, examine equipment, and a few promising purposes. the themes mentioned within the booklet contain electrochemical detection of DNA hybridization in line with latex/gold nanoparticle and Read more...

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5 nM. This aptamer binds to the heparin-binding exosite of thrombin. RNA aptamers for thrombin have also been selected. Ikebukuro et al. [12] first reported an electrochemical aptasensor for the detection of thrombin based on a sandwich-based assay. Two different aptamers specific for thrombin were used: the 29mer thiolated aptamer and the 15-mer aptamer labeled with glucose dehydrogenase (GDH). The thiolated aptamer was immobilized onto gold electrodes; thrombin at different concentrations and then the enzyme-labeled aptamer was added to the aptamer-modified electrodes.

73, 1969–1977 (2001). 6. D. R. Thevenot, K. Toth, R. A. Durst, and G. S. Wilson, Pure Appl. Chem. 71, 2333–2348 (1999). 7. K. M. Millan and S. R. Mikkelsen, Anal. Chem. 65, 2317–2323 (1993). 8. J. Labuda, A. M. O. Brett, G. Evtugyn, M. Fojta, M. Mascini, M. Ozsoz, I. Palchetti, E. Paleˇcek, and J. Wang, Pure Appl. Chem. 82, 1161–1187 (2010). 1351/PAC-REP-09-08-16. 9. E. Palecek, and I. Postbieglova, J. Electroanal. Chem. 214, 359 (1986). 10. R. A. Durst, A. J. Baumner, R. W. Murray, R. P. Buck, and C.

March 19, 2012 18:56 PSP Book - 9in x 6in Detection of Specific DNA Interactions of the metal complex indicator that binds to DNA (such as [Co(phen)3 ]3+ [14, 44–46]) or into enhancement of the voltammetric response of the negatively charged metal complex like [Fe(CN)6 ]3–/4– , which is repulsed by the negatively charged DNA layer depending on the degree of DNA damage [47, 48]. Change in the indicator electrochemical response depends on the portion of DNA damaged in the cleavage reaction. Similarly, a decrease in the charge transfer resistance at an impedimetric biosensor with hexacyanoferrate as the redox indicator in solution was used [47, 48].

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