By Sara Fuchs (auth.), W. Arber, S. Falkow, W. Henle, P. H. Hofschneider, J. H. Humphrey, J. Klein, P. Koldovský, H. Koprowski, O. Maaløe, F. Melchers, R. Rott, H. G. Schweiger, L. Syruĉek, P. K. Vogt (eds.)
The learn of the genetic rules of immune reaction to common multidetermi nant immunogens was once undertaken by means of the tactic of bidirectional selective breed ing of excessive or Low antibody responder strains of mice. 5 decisions are defined: choice I, conducted for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in every one iteration. choice II, performed for agglutinin responsiveness to sheep erythrocytes repeated in each one new release. choice III and choice IV played respectively for agglutinin reaction to flagellar or somatic antigens of Salmonella typhimurium and Salmonella oranienburg alternated in each one new release. choice V, played for passive agglutinin reaction to bovine serum albumin and rabbit gamma globulin alternated in each one new release. In each one choice the nature investigated is polygenic. low and high responder traces diverge gradually throughout the selective breeding. The maximal interline separation (selection restrict) is reached within the 7th-16th generations. low and high responder traces at choice restrict are thought of homozygous for the nature submitted to se~ection. Their variance is as a result purely as a result of environ psychological results. the adaptation in agglutinin titre among low and high strains is 220-fold in choice I, 103-fold in choice II, 90-fold in choice III, 85-fold in choice IV and 275-fold in choice V. The partition of genetic and environmental variances within the origin popu lations of the 5 choices is verified. the share of genetic variance is 60% in choice I; forty nine% in choice II; fifty one% in choice III; forty seven% in choice IV and seventy six% in choice V.
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Extra resources for Current Topics in Microbiology and Immunology
E. Dissociation Between the Genetic Control of Humoral and Cell-Mediated Immune Response. . . . . . . . . . . . . VI. Relationship Between Genetic Regulation of Immunoresponsiveness and Resistance to Aggression. . . . . A. Anti-Infection Immunity . . . 1. Macrophage Dependent Immunity 2. Antibody Dependent Immunity. B. Anti-Helminthic Immunity C. Anti-Tumoral Immunity . . 1. Allogeneic Tumors . . 2. Syngeneic Tumors . . 3. Carcinogen Induced Tumors 4.
Remission of myasthenia gravis following plasma-exchange. : On the significance of HL-A and LD antigens in myasthenia gravis. Ann. Y. Acad. Sci. : Regulation of acetylcholine receptor biosynthesis and degradation during differentiation of muscle cells in culture. Isr. J. Med. Sci. : Appearance and disappearance of acetylcholine recep. tor during differentiation of chick skeletal muscle in vitro. : Ligand-induced changes in stability and distribution of acetylcholine receptors on surface membranes of muscle cells in culture.
Ann. Y. Acad. Sci. : Experimental myasthenia gravis in neonatally thymectomized rabbits. : Remission of myasthenia gravis following plasma-exchange. : On the significance of HL-A and LD antigens in myasthenia gravis. Ann. Y. Acad. Sci. : Regulation of acetylcholine receptor biosynthesis and degradation during differentiation of muscle cells in culture. Isr. J. Med. Sci. : Appearance and disappearance of acetylcholine recep. tor during differentiation of chick skeletal muscle in vitro. : Ligand-induced changes in stability and distribution of acetylcholine receptors on surface membranes of muscle cells in culture.
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