By Beverly A. Teicher

Beverly Teicher and a panel of wonderful investigators survey the cutting-edge of antiangiogenesis examine from the lab bench to medical trials. well timed and authoritative, the individuals summarize our present realizing of tumor progress and its dependence on vascular improvement, in addition to the current prestige of antiangiogenic brokers in preclinical and medical improvement. furthermore, the booklet additionally examines what's recognized concerning the mechanisms through which those healing brokers intrude with tumor vasculature and grapples with the matter of building standards through which to evaluate their medical efficacy. Antiangiogenic brokers in melanoma remedy deals a special state-of-the-art compendium of antiangiogenic examine, taking inventory of what has been complete , the place the experimental therapeutics of antiangiogenic brokers goes, and the continued evolution in their function in melanoma remedy and novel drug improvement.

Show description

Read or Download Antiangiogenic Agents in Cancer Therapy (Cancer Drug Discovery and Development) PDF

Best hematology books

Killer lymphocytes

We have now identified in regards to the lifestyles of killer lymphocytes on the grounds that 1960, after they have been found in reference to transplant rejection in vivo. for the reason that then we now have exposed no less than 5 subsets of lymphocytes which can kill different cells in vitro, developing the research of cell-mediated cytotoxicity (CMC) as an immense box of immunological inquiry.

Disease of Virgins: Green Sickness, Chlorosis and the Problems of Puberty

From an acclaimed writer within the box, it is a compelling research of the origins and historical past of the ailment quite often obvious as afflicting younger single women. figuring out of the grew to become puberty and virginity into health conditions, and Helen King stresses the continuity of this affliction via history,depsite huge, immense shifts in clinical knowing and technonologies, and drawing parallels with the trendy ailment of anorexia.

Cell Membrane: The Red Blood Cell as a Model

This book provides the constitution and serve as of organic membranes to enhance the certainty of cells in either basic and pathogenic states. lately, big quantities of latest details were gathered, specially approximately pathological stipulations, and there's now a lot proof correlating genotypes and phenotypes in basic and illness states.

A Pattern Approach to Lymph Node Diagnosis

Whereas a trend method of analysis is taught and practiced with virtually any other tissue or organ within the physique, the lymph node continues to be a secret to so much citizens beginning out in pathology and people pathologists with restricted adventure within the region. A trend method of Lymph Node analysis demonstrates systematic method of lymph node exam might be completed via acceptance of morphological styles produced via varied affliction tactics.

Extra resources for Antiangiogenic Agents in Cancer Therapy (Cancer Drug Discovery and Development)

Sample text

50. , Cosser, M. , and Guichard, M. (1992) Feasibility of measuring oxygen tension in uterine cervix carcinoma. Eur. J. Cancer 28, 1354–1357. 51. , Le Ridant, A. , et al. (1993) Oxygenation of head and neck tumors. Cancer 71, 2319–2325. 52. , Thomas, C. , et al. (1994) Oxygen tension measurements in human tumors: the Institut Gustave-Roussy Experience. Radiat. Oncol. Invest. 1, 285–291. 53. , Jungblut, J. , and Suckfull, M. (1990) Distribution of oxygen pressure in the periphery and centre of malignant head and neck tumors, in Clinical Oxygen Pressure Measurement II (Ehrly, A.

Oncol. 24, S64. 6. Teicher, B. , Lazo, J. , and Sartorelli, A. C. (1981) Classification of antineoplasic agents by their selective toxicities towards oxygenated and hypoxic tumor cell. Cancer Res. 41, 73–81. Chapter 2 / Oxygenation of Solid Tumors 33 7. Kennedy, K. A. (1987) Hypoxic cells as specific drug targets for chemotherapy. Anticancer Drug Res. 2, 181–194. 8. , Murphy, B. , Laderoute, K. , Gordon, G. , and Sutherland, R. M. (1991) Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance.

Cancer 74, S247–S251. 55. , Schlenger, K. , and Vaupel, P. (1989) Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. Cancer Res. 49, 3759–3764. 56. Secomb, T. , Ong, E. , and Dewhirst, M. (1995) Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol. 34, 313–316. 57. , Braun, R. , Ong, E. , and Dewhirst, M. (1996) Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

Download PDF sample

Rated 4.08 of 5 – based on 29 votes