By P. Ajmone Marsan, L. Colli, E. L. Nicolazzi, R. Negrini, M. Zjalic, A. Rosati (auth.), I. Casasús, J. Rogošiç, A. Rosati, I. à tokoviç, D. Gabiña (eds.)

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1998. Likelihood ratio testing of variance components in the linear mixed-effects model using restricted maximum likelihood. Biometrics 54: 1560-1568. , M. Olivan, R. Celaya, and A. Martinez, 1999. Effects of genotype on the performance and intake characteristics of sheep grazing contrasting hill vegetation communities. Anim. Sci. 69: 419-426. , A. Waterhouse, S. Thomson, A. Midgeley, J. Vipond, G. Hill, C. P Holland, M. Pollock and M. Williams, 2008. Farmings retreat from the hills. Edinburgh, UK: SAC Rural Policy Centre.

Igf2 encodes a paternally expressed growth enhancer, whereas the insulin-like receptor gene (Igf2r) encodes a maternally expressed growth inhibitor that degrades Igf2 (Haig and Graham 1991). Further, loss of imprinting at the Igf2 locus results in bi-allelic expression of this growth factor in 10% of adult humans and is associated with increased cancer rate. The Igf axis plays roles in promoting cell proliferation and inhibiting cell death. Insulin-like growth factor 1 (Igf1) is mainly secreted by the liver as a result of stimulation by growth hormone.

W. Hoek, E. S. Brown, A. G. E. M. C. S. Kahn, 2000. Prenatal exposure to famine and brain morphology in schizophrenia. American Journal of Psychiatry 157: 1170-1172. 42  Animal farming and environmental interactions in the Mediterranean region Huw Jones, R. E. Ozanne, 2009. Fetal programming of glucose-insulin metabolism. Molecular and Cellular Endocrinology 297: 4-9. , 2005. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity.

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