By Wojciech Gorczyca
This vast reference protecting neoplastic hematopathology contains over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and typically affected extranodal organs, with designated emphasis at the differential prognosis. It discusses simple scientific, prognostic, morphologic and phenotypic info, with a number of tables summarizing the phenotypic profiles of the most typical hematologic tumors. an immense function of this ebook is an method of hematologic tumors in response to the WHO type, with appropriate examples and emphasis at the most valuable morphologic and immunophenotypic good points utilized in diagnosis.It should be a useful reference for all training hematologists, oncologists and pathologists.
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Extra info for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
11 Flow cytometry immunophenotyping—concept of the intensity of staining and coexpression of antigens (see text for details) moderate expression of CD3. Bright staining is at least two log decades brighter than negative control. 11C) display bright expression of CD11c and CD3, respectively. 11D shows B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL; green) with dim expression of CD20 (x-axis) and positive expression of lambda immunoglobulins (y-axis). As illustrated, FC gives information about the presence or absence of a given antigen as well as its intensity of expression.
If the B-cell encounters its antigen match, the B-cell will undergo clonal expansion, making millions of copies of itself and differentiating into special types of Bcells eventually transforming into a plasma cell. Plasma cells secrete their immunoglobulin antibodies from their cytoplasm into the serum, thereby enabling the infection or intruder proteins to be eliminated. Programmed cell death (apoptosis), as well as suppressor T-cells, prevents the clonal cells from becoming autonomous, immortal and hence neoplastic.
Gating on cells with moderate CD20 and low forward scatter (D) yields polytypic cells (see histograms on the right). Gating on cells with bright CD20 expression and slightly higher forward scatter (E) yields monoclonal lambda+ population (arrow, histograms on the right). 13 Flow cytometry immunophenotyping—gating strategy 24 Introduction 25 based on the intensity of CD20 expression (see text for details) Prognostic markers Determination of the expression of ZAP70 and/or CD38 by FC can serve as a prognostic marker in patients with B-chronic lymphocytic leukemia (B-CLL).
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